Разработка научного обоснования оптимизации природопользования особо охраняемых природных территорий регионального значения

В условиях Кемеровской области, где большая часть территорий распределена между природопользователями, организация мероприятий по ограничению хозяйственного использования на новых участках крайне затруднительна. В этой связи единственным реальным подходом снижения комплексных антропогенных воздействий, в том числе и рекреационных, может быть разработка и внедрение новых механизмов оптимизации сохранения природных комплексов.In the Kemerovo region, where most of the territories are distributed among nature users, the organization of measures to limit economic use in new areas is extremely difficult. In this regard, the only realistic approach to reducing complex anthropogenic impacts, including recreational ones, can be the development and implementation of new mechanisms for optimizing the conservation of natural complexes

Fluid-induced coagulopathy: does the type of fluid make a difference?

Crystalloid and colloid solutions are used for resuscitation of the critically ill. One set of options, widely used today, are different preparations of hydroxyethyl starch (HES). However, the safety of HES regarding impairment of blood coagulation remains incompletely elucidated, a circumstance that limits its clinical use. Understanding mechanisms and potential differences between low-molecular and low-substituted HES and other HES solutions seems clinically relevant

Efficacy and safety of early target-controlled plasma volume replacement with a balanced gelatine solution versus a balanced electrolyte solution in patients with severe sepsis/septic shock: study protocol, design, and rationale of a prospective, randomized, controlled, double-blind, multicentric, international clinical trial

Col·loides; Gelatina; SèpsiaColoides; Gelatina; SepticemiaColloids; Gelatine; SepsisBackground Sepsis is associated with capillary leakage and vasodilatation and leads to hypotension and tissue hypoperfusion. Early plasma volume replacement is required to achieve haemodynamic stability (HDS) and maintain adequate tissue oxygenation. The right choice of fluids to be used for plasma volume replacement (colloid or crystalloid solutions) is still a matter of debate, and large trials investigating the use of colloid solutions containing gelatine are missing. This study aims to investigate the efficacy and safety of plasma volume replacement using either a combined gelatine-crystalloid regime (1:1 ratio) or a pure crystalloid regime. Methods This is a prospective, controlled, randomized, double-blind, international, multicentric phase IV study with two parallel groups that is planned to be conducted at European intensive care units (ICUs) in a population of patients with hypovolaemia in severe sepsis/septic shock. A total of 608 eligible patients will be randomly assigned to receive either a gelatine-crystalloid regime (Gelaspan® 4% and Sterofundin® ISO, B. Braun Melsungen AG, in a 1:1 ratio) or a pure crystalloid regime (Sterofundin® ISO) for plasma volume replacement. The primary outcome is defined as the time needed to achieve HDS. Plasma volume replacement will be target-controlled, i.e. fluids will only be administered to volume-responsive patients. Volume responsiveness will be assessed through passive leg raising or fluid challenges. The safety and efficacy of both regimens will be assessed daily for 28 days or until ICU discharge (whichever occurs first) as the secondary outcomes of this study. Follow-up visits/calls will be scheduled on day 28 and day 90. Discussion This study aims to generate evidence regarding which regimen—a gelatine-crystalloid regimen or a pure crystalloid regimen—is more effective in achieving HDS in critically ill patients with hypovolaemia. Study participants in both groups will benefit from the increased safety of target-controlled plasma volume replacement, which prevents fluid administration to already haemodynamically stable patients and reduces the risk of harmful fluid overload.In this clinical study, B. Braun Melsungen AG, Carl-Braun Str. 1, D-34212 Melsungen acts as the sponsor, funder and data holder of this study. Additionally, it is the manufacturer of IMP, as well as the co-author and medical writer of this manuscript. B. Braun Melsungen AG organized protocol development and contracted a contract research organization (CRO) for clinical trial application, monitoring, and collection/analysis of study data. Investigational tests and reference products will be produced and delivered by B. Braun Melsungen AG to all participating sites. Open Access funding enabled and organized by Projekt DEAL

Clean and efficient extraction of copper ions and deposition as metal

AbstractA simple, clean and efficient one-pot process is offered as an alternative to the conventional complex processing presently used to extract copper ions from copper containing materials, like copper concentrate or slag, and to form copper metal. The alternative process uses a eutectic molten salt of potassium chloride, sodium chloride and zinc chloride as the reaction fluid which is recyclable, low in cost, environmentally benign, low melting (melting point 204°), high boiling (vapor pressure is only a few psi at 800°) and chemically, thermally and physically stable. The metal completely dissolves out of copper concentrate or slag in the aerobic eutectic molten chloride salt in a graphite or glassy carbon pot, which serves as a cathode, with a graphite anode, to reduce the metal ions to metal which sinks to the bottom of the graphite pot. The total efficiency for extraction and deposition is virtually 100% as determined by elemental and gravimetric analyses

Разработка автоматизированной системы групповой замерной установки

Создание информационно-измерительной системы, подбор контроллерного оборудования, исполнительных устройств, алгоритмов управления для групповой замерной установки.Creation of information-measuring system, selection of controller equipment, actuators, control algorithms for group metering installation